The Trial Master File (TMF) or its modern form, the Electronic Trial Mater File (eTMF), is a collection of essential documents that are collected during the course of a clinical trial. This group of documents allows the conduct of a clinical trial to be reconstructed and evaluated at any point in time and provides a story of how the trial was managed and carried out. This collection of documents has to be updated regularly and the eTMF completeness evaluated continuously.
